Role of surgical resection for hepatocellular carcinoma based on Japanese clinical guidelines for hepatocellular carcinoma

Table 2 Treatment options for hepatocellular carcinoma in barcelona clinic liver cancer system and Japanese guidelines

Tumor number	Tumor size (cm)	Child-Pugh class	Treatment
			BCLC system	Japanese guidelines
Single	2	A, B	Resection	1 Resection
				2 Ablation
	2.1-3	A, B	1 Resection	1 Resection
			2 Transplantation or ablation	2 Ablation
	3.1-5	A, B	1 Resection	Resection
			2 Transplantation
2 or 3 nodules	≤ 3	A, B	Transplantation or ablation	Resection or ablation
		C	Palliative care	Transplantation
	> 3	A, B	Chemoembolization	1 Resection
				2 Chemoembolization
4 or more nodules		A, B	Chemoembolization	1 Chemoembolization
				2 Chemotherapy
		C	Palliative care	Palliative care

Degree of Liver damage replaced Child-Pugh classification as liver function in Japan Revise from ref. [22].