Antiviral treatment for chronic hepatitis B in renal transplant patients

Table 1 Dosage adjustment of nucleos(t)ide analogue for patients with reduced creatinine clearance

	Recommended dosage		Dosage forms
Creatinine clearance (mL/min)	Lamivudine[25]		Lamivudine[25]
> 50	100 mg once daily		Tablets: 100 mg
30-49	100 mg first dose, then 50 mg once daily		Oral solution: 10 mg/mL
15-29	100 mg first dose, then 25 mg once daily
5-14	35 mg first dose, then 15 mg once daily
< 5	35 mg first dose, then 10 mg once daily
	Adefovir[26]		Adefovir[26]
> 50	10 mg every 24 h		Tablets: 10 mg
30-49	10 mg every 48 h		Oral solution: not available
10-29	10 mg every 72 h
Hemodialysis	10 mg every 7 d following dialysis
	Telbivudine[27]		Telbivudine[27]
> 50	600 mg every 24 h		Tablets: 600 mg
30-49	600 mg every 48 h		Oral solution: 100 mg/5 mL
10-29	600 mg every 72 h
Hemodialysis	600 mg every 96 h following dialysis
	Entecavir[28]	Entecavir in Lamivudine-Refractory[28]	Entecavir[28]
> 50	0.5 mg once daily	1 mg once daily	Tablets: 0.5 mg and 1 mg Oral solution: 0.05 mg/mL
30-49	0.25 mg once daily OR	0.5 mg once daily OR
	0.5 mg every 48 h	1 mg every 48 h
10-29	0.15 mg once daily OR	0.3 mg once daily OR
	0.5 mg every 72 h	1 mg every 72 h
Hemodialysis	0.05 mg once daily OR	0.1 mg once daily OR
	0.5 mg every 7 d following dialysis	1 mg every 7 d following dialysis
	Tenofovir[29]		Tenofovir[29]
> 50	300 mg every 24 h		Tablets: 300 mg
30-49	300 mg every 48 h		Oral powder: 40 mg per 1 g of oral powder
10-29	300 mg every 72 to 96 h
Hemodialysis	300 mg every 7 d or after approximately 12 h of dialysis