Hepatitis C cirrhosis: New perspectives for diagnosis and treatment

doi:10.4254/wjh.v7.i14.1843

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jul 18, 2015; 7(14): 1843-1855
Published online Jul 18, 2015. doi: 10.4254/wjh.v7.i14.1843

Table 7 Summary of sofosbuvir and ledipasvir trials and enrollment of cirrhotic patients

Trial	Regimen	Patient population (% with cirrhosis)	Duration (wk)	SVR12
ION-1[45]	SOF + LDP	212 naïve (16%)	12	99%
	SOF + LDP + RBV	211 naïve (15%)	12	97%
	SOF + LDP	214 naïve (15%)	24	98%
	SOF + LDP + RBV	215 naïve (17%)	24	99%
ION-2[46]	SOF + LDP	109 treatment experienced (20%)	12	94%
	SOF + LDP + RBV	111 treatment experienced (20%)	12	96%
	SOF + LDP	109 treatment experienced (20%)	24	99%
	SOF + LDP + RBV	111 treatment experienced (20%)	24	99%
ION-3[47]	SOF + LDP	215 naïve (0%)	8	94%
	SOF + LDP + RBV	216 naïve (0%)	8	93%
	SOF + LDP	216 naïve (0%)	12	95%

SOF: Sofosbuvir; LDP: Ledipasvir; RBV: Ribavirin; SVR12: Sustained virologic response at 12 wk.

Citation: Khullar V, Firpi RJ. Hepatitis C cirrhosis: New perspectives for diagnosis and treatment. World J Hepatol 2015; 7(14): 1843-1855
URL: https://www.wjgnet.com/1948-5182/full/v7/i14/1843.htm
DOI: https://dx.doi.org/10.4254/wjh.v7.i14.1843