Relevance of ADAMTS13 to liver transplantation and surgery

Figure 5 Perioperative changes of a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 activity and unusually large von Willebrand factor multimers in a patient with large hepatectomy. The patient underwent long Pringles’s maneuver (75 min). While ADAMTS13 did not decrease during hepatectomy even with long ischemic time by hepatic inflow occlusion, the activity markedly decreased until the next day. Consistently, UL-VWFM did not appeared during hepatectomy, and significantly up-regulated from day 3. Pre: Before transplantation; NP: Normal plasma controls; UL-VWFM: Unusually large von Willebrand factor multimers; ADAMTS13: A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13.