Meta-Analysis
Copyright ©The Author(s) 2015.
World J Hepatol. Jul 8, 2015; 7(13): 1797-1806
Published online Jul 8, 2015. doi: 10.4254/wjh.v7.i13.1797
Table 1 Checklist summarizing compliance with meta-analysis of observational studies in Epidemiology Guidelines
MOOSE criteriaaMet (yes/no)
Reporting background should include
Problem definitionYes
Hypothesis statementNo
Description of study outcome(s)Yes
Type of exposure or intervention usedYes
Type of study designs usedYes
Study populationYes
Reporting of search strategy should include
Qualifications of searchers (e.g., librarians and investigators)Yes
Search strategy, including time period included in the synthesis and keywordsYes
Effort to include all available studies, including contact with authorsYes
Databases and registries searchedYes
Search software used, name and version, including special features used (e.g., explosion)Yes
Use of hand searching (e.g., reference lists of obtained articles)Yes
List of citations located and those excluded, including justificationYes
Method of addressing articles published in languages other than EnglishYes
Method of handling abstracts and unpublished studiesNo
Description of any contact with authorsNo
Reporting methods should include
Description of relevance or appropriateness of studies assembled for assessing the hypothesis to be testedYes
Rationale for the selection and coding of data (e.g., sound clinical principles or convenience)Yes
Documentation of how data were classified and coded (e.g., multiple raters, blinding, and interrater reliability)Yes
Assessment of confounding (e.g., comparability of cases and controls in studies where appropriate)No
Assessment of study quality, including blinding of quality assessors; stratification or regression on possible predictors of study resultsYes
Assessment of heterogeneityYes
Description of statistical methods (e.g., complete description of fixed or random effects models, justification of whether the chosen models account for predictors of study results, dose-response models, or cumulative meta-analysis) in sufficient detail to be replicatedYes
Provision of appropriate tables and graphicsYes
Reporting of results should include
Graphic summarizing individual study estimates and overall estimateYes
Table giving descriptive information for each study includedYes
Results of sensitivity testing (e.g., subgroup analysis)No
Indication of statistical uncertainty of findingsYes
Reporting of discussion should include
Quantitative assessment of bias (e.g., publication bias)NA
Justification for exclusion (e.g., exclusion of non-English-language citations)Yes
Assessment of quality of included studiesYes
Reporting of conclusions should include
Consideration of alternative explanations for observed resultsYes
Generalization of the conclusions (e.g., appropriate for the data presented and within the domain of the literature review)Yes
Guidelines for future researchYes
Disclosure of funding sourceYes