Treatment of chronic hepatitis C in liver transplant candidates and recipients: Where do we stand?

doi:10.4254/wjh.v7.i12.1606

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jun 28, 2015; 7(12): 1606-1616
Published online Jun 28, 2015. doi: 10.4254/wjh.v7.i12.1606

Table 5 Treatment of hepatitis C virus recurrence post liver transplant

IFN-free: Sofosbuvir + RBV (HCV genotype 2 for 12-24 wk); sofosbuvir + daclatasvir ± RBV (HCV genotypes 1, 3-6 for 12-24 wk); sofosbuvir + simeprevir ± RBV (HCV genotypes 1, 4 for 12 -24 wk)
In case of restriction applying first generation DAAs
Fibrosis metavir stage 3-4	Genotype 2/3	Genotype 1
Genotype 1a		Fibrosis metavir stage 2
IL-28B polymorphism		Predictors of poor response
Fibrosing cholestatic hepatitis	Peg-IFN plus RBV	Peg-IFN plus RBV plus boceprevir or telaprevir
Non responders to previous treatments	Monitor closely Hb, WBC, PLTs CNI levels, renal function
	Consider
	Administration of blood transfusions, EPO, CSGF
	Decrease of RBV dose
	Renal dose adjustment
	Decrease of CNI dose

IFN: Interferon; RBV: Ribavirin; CNI: Calcineurin inhibitor; HCV: Hepatitis C virus; Peg-IFN: Pegylated interferon; DAA: Direct antiviral agent; WBC: White cells blood count; PLTs: Platelets; EPO: Erythropoietin; CSGF: Granulocyte-colony stimulating factor.

Citation: Pipili C, Cholongitas E. Treatment of chronic hepatitis C in liver transplant candidates and recipients: Where do we stand? World J Hepatol 2015; 7(12): 1606-1616
URL: https://www.wjgnet.com/1948-5182/full/v7/i12/1606.htm
DOI: https://dx.doi.org/10.4254/wjh.v7.i12.1606