Current and future directions for treating hepatitis B virus infection

Table 4 Treatment efficacy of entecavir in chronic hepatitis B

Ref.	No. of patients	HBeAg	Therapy regimen	HBeAg loss (%)/seroconversion from HBeAg to anti-HBe (%)	Undetectable of HBV DNA (%)	Normalization of ALT (%)	HBsAg loss (n)
1Chang et al[66]	354 NUCs - treatment-naive	Positive	ETV 0.5 mg daily for 48 wk	22/21	67	68	6
	355 NUCs - treatment-naive	Positive	LAM 100 mg daily for 48 wk	20/18	36	60	4
2Gish et al[67]	243 NUCs - treatment-naive	Positive	ETV 0.5 mg daily for 2 yr	NA/31	80	87	18
	164 NUCs - treatment-naive	Positive	LAM 100 mg daily for 2 yr	NA/26	39	79	10
1Lai et al[70]	296	Negative	ETV 0.5 mg daily for 48 wk	NA/NA	90	78	1
	287	Negative	LAM 100 mg daily for 48 wk	NA/NA	72	71	1

Treatment efficacies were assessed at 48 wk¹, or 2 years². ETV: Entecavir; NUCs: Nucleos(t)ide analogues; NA: Not available; LAM: Lamivudine; HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus; ALT: Alanine aminotransferase; HBsAg: Hepatitis B surface antigen; Anti-HBe: Antibody to HBe antigen.