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©The Author(s) 2015.
World J Hepatol. Jun 18, 2015; 7(11): 1494-1508
Published online Jun 18, 2015. doi: 10.4254/wjh.v7.i11.1494
Published online Jun 18, 2015. doi: 10.4254/wjh.v7.i11.1494
Table 5 Clinical data of immune modulation by intravenous immunoglobulins in ABO-incompatible liver transplant recipients
Ref. | Transplant | No. of patients receiving | Additional immune modulation | Efficacy of IVIg on immunology/survival |
procedure | IVIg (pre-LT/post-LT) | |||
Morioka et al[167] | LDLT | n = 2; post-LDLT; treatment of AMR | Plasmapheresis | Normalization of liver function; survived |
Urbani et al[170] | LT | n = 1; post-LT; treatment of AMR | Plasmapheresis | Normalization of liver function; survived |
Ikegami et al[168] | LDLT | n = 1; post-LDLT; treatment of AMR | Rituximab, plasma exchange, splenectomy | Normalization of liver function; survived |
Testa et al[169] | LDLT | n = 5; pre-LDLT | Plasmapheresis, splenectomy | Patient and graft survival 80% at mean of 43 mo post-LDLT |
Urbani et al[172] | LT | n = 8; pre- and post-LT | Plasma exchange | Patient and graft survival 87.5% at 18 mo; no case of acute or chronic rejection, no ITBL |
Ikegami et al[161] | LDLT | n = 4; post-LDLT | Rituximab, plasma exchange, splenectomy | Survival rate 100% (28, 8, 6, 5 mo post-LDLT) |
Takeda et al[173] | LDLT | n = 3; post-LDLT; treatment of AMR | Plasma exchange | Normalization liver function; survived |
Mendes et al[174] | LT | n = 10; pre- and post-LT | Rituximab, plasmapheresis | Survival rate 50%; death mainly related to MOF and sepsis |
Kim et al[175] | LDLT | n = 14; post-LDLT | Rituximab, plasma exchange | Survival 100%; no case of acute or chronic rejection |
Lee et al[176] | LDLT | n = 15; post-LT | Rituximab, plasma exchange | Survival 100%; no case of bacterial or fungal infection; 3 cases of biliary strictures |
Shen et al[177] | LT | n = 35; pre- and post-LT | Rituximab | Survival rate 83.1% at 3-yr; one case of acute celluar rejection; two cases of AMR |
- Citation: Kornberg A. Intravenous immunoglobulins in liver transplant patients: Perspectives of clinical immune modulation. World J Hepatol 2015; 7(11): 1494-1508
- URL: https://www.wjgnet.com/1948-5182/full/v7/i11/1494.htm
- DOI: https://dx.doi.org/10.4254/wjh.v7.i11.1494