Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma

doi:10.4254/wjh.v7.i1.1

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jan 27, 2015; 7(1): 1-6
Published online Jan 27, 2015. doi: 10.4254/wjh.v7.i1.1

Table 1 Representative noncoding RNAs in sera for Hepatocellular carcinoma diagnosis

MiRNA	Expression levels in HCC	Possible targets	Ref.
MiR21	Upregulated	PTEN, AKT, C/EBPb	[32,39,58]
MiR222	Upregulated	PP2A, p27, DDIT4	[42,43,59]
MiR223	Upregulated	Stathmin	[44]
HULC	Upregulated	IGF2BP1	[45-47]

HCC: Hepatocellular carcinoma; HULC: Highly up-regulated in liver cancer; PTEN: Phosphatase and tensin-like protein; AKT: V-akt murine thymoma viral oncogene homolog; C/EBPb: CCAAT/enhancer-binding protein beta; PP2A: Protein phosphatase 2A; IGF2BP1: Insulin-like growth factor 2 MRNA binding protein 1.

Citation: Shibata C, Otsuka M, Kishikawa T, Ohno M, Yoshikawa T, Takata A, Koike K. Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma. World J Hepatol 2015; 7(1): 1-6
URL: https://www.wjgnet.com/1948-5182/full/v7/i1/1.htm
DOI: https://dx.doi.org/10.4254/wjh.v7.i1.1