Nucleos(t)ide analogues to treat hepatitis B virus-related hepatocellular carcinoma after radical resection

Table 2 Survival outcomes of patients with hepatitis B virus-related hepatocellular carcinoma treated with nucleos(t)ide analogues or not after radical resection

Year ofpublication	Ref.	Group	n	Overall survival rate (%)				Recurrence-free survival rate (%)
				1 yr	3 yr	5 yr	P	1 yr	3 yr	5 yr	P
2005	Piao et al[21]	NAs	30	100	91.3	N/A	0.12	75	46	N/A	> 0.05
		Control	40	92.4	66	N/A		58	22	N/A
2006	Shuqun et al[22]	NAs	16	24	N/A	N/A	0.0053	19.7	N/A	N/A	> 0.05
		Control	17	0	N/A	N/A		4.5	N/A	N/A
2007	Kuzuya et al[23]	NAs	16	100	100	N/A	0.063	86.5	64.9	N/A	0.622
		Control	33	86.6	46.8	N/A		86.6	46.8	N/A
2007	Kubo et al[24]	NAs	14	N/A	N/A	N/A	N/A	90	90	78	0.0086
		Control	10	N/A	N/A	N/A		55	28	28
2008	Hung et al[25]	NAs	10	N/A	N/A	N/A	N/A	90	N/A	N/A	0.03
		Control	62	N/A	N/A	N/A		75	N/A	N/A
2008	Yoshida et al[26]	NAs	33	100	80	59	> 0.05	N/A	N/A	N/A	> 0.05
		Control	71	100	85	70		N/A	N/A	N/A
2009	Koda et al[27]	NAs	30	96	76	76	0.02	65	15	N/A	> 0.05
		Control	20	86	48	32		72	30	N/A
2009	Chuma et al[28]	NAs	20	N/A	N/A	N/A	N/A	90	55	45	> 0.05
		Control	64	N/A	N/A	N/A		85.9	50	43.7
2010	Li et al[29]	NAs	43	41.9	N/A	N/A	0.0094	23.3	N/A	N/A	0.072
		Control	36	33.3	N/A	N/A		8.3	N/A	N/A
2011	Chan et al[30]	NAs	42	88.1	79.1	71.2	0.005	66.5	51.4	51.4	0.05
		Control	94	76.5	47.5	43.5		48.9	33.8	33.8
2012	Wu et al[31]	NAs	518	94	81	73	0.002	87	66	54	< 0.001
		Control	4051	91	74	62		78	56	47
2012	Urata et al[32]	NAs	46	100	97.1	89.7	0.0025	71.6	56.8	42.6	0.0478
		Control	13	84.6	68.4	59.8		61.5	19.2	19.2
2013	Ke et al[33]	NAs	141	92.1	84.4	79.1	0.009	73.1	54.7	44.5	0.503
		Control	141	89.6	66.3	52.1		68.8	47.8	43
2013	Yin et al[38]	NAs	81	98	88	N/A	< 0.001	81	46	N/A	< 0.001
		Control	82	86	51	N/A		50	20	N/A
		NAs	215	84	60	N/A	0.04	52	37.5	N/A	< 0.001
		Control	402	75	50	N/A		43	21	N/A
2013	Su et al[34]	NAs	62	99	96	89	< 0.001	90	64	58	< 0.001
		Control	271	84	64	49		64	44	34
2013	Yan et al[35]	NAs	35	N/A	N/A	N/A	N/A	74.3	11.4	N/A	0.283
		Control	25	N/A	N/A	N/A		80	0	N/A
2014	Hann et al[37]	NAs	16	100	93.8	86.5	< 0.001	81.3	81.3	81.3	< 0.001
		Control	9	55.6	0	0		11.1	0	0
2014	Huang et al[39]	NAs	100	96	77.6	63.1	0.001	85	50.3	46.1	0.026
		Control	100	94	67.4	41.5		84	37.9	27.1

Boldfaced data come from randomized controlled trials in our review[38,39]. N/A: Not applicable; NA: Nucleos(t)ide analogue.