Portal vein thrombosis with protein C-S deficiency in a non-cirrhotic patient

Table 2 Proposed mechanism for reduction in concentrations of procoagulant and anticoagulant proteins in patients with portal vein thrombosis

Hereditary or acquired thrombophilia

Reduced hepatic blood flow

Reduced synthesis

Portal hypertension

Portosystemic shunting

Clearance or consumption

Portal pyaemia or other local inflammatory disease

Portal vein thrombosis

Reduced levels of procoagulant and anticoagulant proteins