NS3 protease inhibitors for treatment of chronic hepatitis C: Efficacy and safety

Table 4 Adverse events under telaprevir-based therapy

Agent RCT	Telaprevir
	Advance		Realize		Illuminate
	PR	T8/12PR	PR48	(lead-in) T12PR48	T12PR24/48
Serious AE	7%	9%	5%	12%	9%
Discontinued AVT due to AE	7%	10%	3%	15%-11%	18%
Anorectal symptoms	4%	8%-13%	7%	15%-12%	-
Taste disturbances	-	-	6%	12%	-
Anemia	19%	39%-37%	15%	30%-36%	39%
Severe neutropenia	19%	17%-14%	11%	14%-13%	-
Rash	24%	35%-37%	19%	37%-36%	37%
Fatigue	57%	58%-57%	40%	55%-50%	68%
Pruritus	36%	45%-50%	27%	52%-50%	51%
Nausea	31%	40%-43%	23%	35%-33%	47%
Diarrhea	22%	32%-28%	14%	25%-26%	30%

AE: Adverse event.; AVT: Antiviral treatment.