Chronic hepatitis B: Advances in treatment

Table 1 European Association for the Study of the Liver guidelines compared to other international guidelines

Criteria	EASL 2012[6]	AASLD 2009[7]	APASL 2012[8]
HBV DNA treatment threshold
HBeAg(+) (IU/mL)	2000	20000	20000
HBeAg(-) (IU/mL)	2000	2000-20000	2000
ALT treatment threshold	> ULN	> 2 × ULN	> 2 × ULN
Liver biopsy	Moderate to severe necroinflammation or fibrosis	Not applicable (consider in certain groups)

ULN: Upper limits of normal; HBeAg: Hepatitis B e antigen; ALT: Alanine aminotransferase; AASLD: American Association for the Study of Liver Diseases; APASL: Asia Pacific Association for the Study of the Liver; EASL: European Association for the Study of the Liver; HBV: Hepatitis B virus.