Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions

Figure 10 RT-PCR and Western blot analyses of autophagy regulators. Both melatonin and cisplatin increased p-mTOR and ERCC 1 levels in the HepG2 cells, but the combined treatment resulted in the suppression of both proteins. (^bP < 0.01, ^cP < 0.001 compared with the control group, ^eP < 0.01, ^fP < 0.001 compared with the cisplatin-treated group). ERCC1: Excision repair cross complementary-1.