Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions

Figure 8 Analysis of autophagy and DNA repair-related proteins. Hepatocellular carcinoma cells were treated with various concentrations of melatonin and cisplatin. At the selected concentrations, 1 mmol/L melatonin and 20 μmol/L cisplatin have a similar effect by significantly increasing p-mTOR and ERCC 1 from the basal levels. However, the effect on Beclin-1 was the opposite, with melatonin increasing Beclin-1 and cisplatin decreasing Beclin-1 from the basal level. The results are presented as the mean ± SE. (^aP < 0.05, ^bP < 0.01, ^cP < 0.001 compared with the control group). ERCC1: Excision repair cross complementary-1.