Mechanisms of fibrogenesis in liver cirrhosis: The molecular aspects of epithelial-mesenchymal transition

doi:10.4254/wjh.v6.i4.207

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Apr 27, 2014 (publication date) through Nov 4, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Apr 27, 2014; 6(4): 207-216
Published online Apr 27, 2014. doi: 10.4254/wjh.v6.i4.207

Table 1 Useful biomarkers for identifying epithelial-mesenchymal transition

Biomarkers	Myofibroblast	Hepatic stellate cell	Hepatocyte	Cholangiocyte
α-SMA¹	+	+	-	-
Vimentin¹	+	+	-	-
Desmin¹	+	+	-	-
ICAM-1	+	+	-	-
Collagen type IV	+	+	-	-
Fibronectin	+	+	-	-
Fibulin-2	+	-	-	-
IL-6 mRNA	+	-	-	-
NCAM	+	-	-	-
Synaptophysin	+	-	-	-
Neurotrophin	+	-	-	-
Neural growth factor	+	-	-	-
αB-crystalline	+	-	-	-
Tyrosine kinase	+	-	-	-
FSP-1¹	+		-	-
HSP47¹	+		-	-
CD95L	-	+	-	-
α2-macroglobulin	-	+	-	-
P100	-	+	-	-
Reelin	-	+	-	-
Fascin	-	+	-	-
E-cadherin	-	-	+	+
Cytokeratin	-	-	+	+
K19	-	-	-	+
Albumin	-	-	+	-
Slug¹	+	?	-	-
Twist¹	+	?	-	-
Snail¹	+	?	-	-

¹Previously proven markers associated with epithelial-mesenchymal transition. α-SMA: α-smooth muscle actin; ICAM-1: Intercellular adhesion molecule-1; IL-6: Interleukin-6; NCAM: Neural cell adhesion molecule; FSP-1: Fibroblast-specific protein-1.

Citation: Lee SJ, Kim KH, Park KK. Mechanisms of fibrogenesis in liver cirrhosis: The molecular aspects of epithelial-mesenchymal transition. World J Hepatol 2014; 6(4): 207-216
URL: https://www.wjgnet.com/1948-5182/full/v6/i4/207.htm
DOI: https://dx.doi.org/10.4254/wjh.v6.i4.207