Thyroid hormone analogues and derivatives: Actions in fatty liver

Figure 4 A summary of key events and molecular pathways underlying T2 (A) and TRC (B) anti-steatotic and hypolipidemic effects (for details see the text). T2: 3,5-diiodo-L-thyronine; TR: Thyroid hormone receptor; COX Va: Cytochrome-c oxidase Va subunit; FFA: Free fatty acid; TG: Triglyceride; P-AMPK: Phosphorylated AMP-activated protein kinase; SIRT1: NAD⁺-dependent deacetylase sirtuin 1; PGC-1α: Peroxisome proliferator-activated receptor γ coactivator; SREBP-1c: Sterol response element binding protein-1c; CPT: Carnitine palmitoyltransferase system; OXPHOS: Oxidative phosphorylation system.