Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis

Figure 4 Methylsulfonylmethane inhibits hepatic tumorigenesis in H-ras^12V transgenic mice. H-ras^12V transgenic mice were administered with PBS and MSM (100 μg/g) every day for 3 mo. A: Liver morphologies of PBS (control) group (left) and MSM group (right) after administration for 3 mo; B: Hematoxylin and eosin stained section in livers of PBS and MSM treated H-ras^12V transgenic mice (Scale bars, 500 μm); C: Expression levels of cleaved PARP in H-ras^12V livers; D: The levels of AST and ALT in plasma of H-ras^12V transgenic mice treated with MSM. MSM: Methylsulfonylmethane; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase.