Mammalian target of rapamycin inhibition in hepatocellular carcinoma

doi:10.4254/wjh.v6.i11.776

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Nov 27, 2014 (publication date) through Aug 24, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Nov 27, 2014; 6(11): 776-782
Published online Nov 27, 2014. doi: 10.4254/wjh.v6.i11.776

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Figure 2 The PI3K/AKT/mTOR pathway. IRS1: Insulin receptor subsrate 1; PI3K: Phophoinositide-3-kinase; PIP-2: Phosphatidylinositol (4,5)-biphosphate; PIP-3: Phosphatidylinositol (3,4,5)-triphosphate; PTEN: Phosphatase and tensin homologue on chromosome 10 gene; PDK1: Phosphoinositide-dependent protein kinase-1; PKB/AKT: Serine/threonine protein kinase; TSC1-TSC2: Tuberous sclerosis 1-tuberous sclerosis 2 complex; 4EBP1: Eukaryotic initiation factor 4E binding protein 1; eIF4E: Eukaryotic initiation factor 4E; S6K1: 70S ribosomal protein S6 kinase; SFKs: SRC family kinases.

Citation: Ashworth RE, Wu J. Mammalian target of rapamycin inhibition in hepatocellular carcinoma. World J Hepatol 2014; 6(11): 776-782
URL: https://www.wjgnet.com/1948-5182/full/v6/i11/776.htm
DOI: https://dx.doi.org/10.4254/wjh.v6.i11.776