Circulating microRNA, miR-122 and miR-221 signature in Egyptian patients with chronic hepatitis C related hepatocellular carcinoma

Table 1 Demographic parameters of patients

	HCC (n = 30)	Cirrhosis (n = 30)	CH (n = 30)	Normal (n = 10)	P value
Age (yr) Mean ± SD	60.27 ± 8.20C	55.07 ± 7.35B	38.20 ± 8.21A	40.89 ± 16.85A	≤ 0.001
Gender (male)	25 (83.3)	21 (70)	22 (73.3)	6 (66.7)	0.6
Hb (g/dL )	11.44 ± 2.85B	10.53 ± 2.00B	14.23 ± 1.58A	14.03 ± 2.48A	< 0.001
WBC × 103/mm3	5.73 ± 2.56A	7.08 ± 3.77A	6.15 ± 2.13A	7.38 ± 2.72A	0.217
Platelets 10/mm3D	126.00 ± 74.05B	116.10 ± 68.94B	228.80 ± 59.74A	271.3 ± 116.7A	< 0.001
Total bilirubin (0.1-1.2 mg/dL)	1.88 ± 2.01A	4.29 ± 6.75B	0.74 ± 0.26A	0.79 ± 0.36A	< 0.001
ALT (0-42 IU/L)	66.59 ± 44.59B	32.15 ± 23.59A	66.78 ± 36.56B	29.16 ± 19.96A	< 0.001
AST (0-42 IU/L)	119.99 ± 56.12B	63.81 ± 39.49A	59.67 ± 45.04A	45.64 ± 54.32A	< 0.001
ALP (0-290 IU/L)D	394.8 ± 282.28A	304.89 ± 191.85A	203.58 ± 82.37AB	198.8 ± 139.1B	0.003
Albumin (3.5-5.5 g/dL)D	3.16 ± 0.40C	2.49 ± 0.54B	4.22 ± 0.36A	4.09 ± 0.92A	< 0.001
PC %	69.63 ± 16.25C	51.58 ± 17.12B	88.24 ± 10.89A	97.63 ± 11.77A	< 0.001
AFP log10 ng/dL	2.50 ± 1.19B	0.79 ± 0.54A	0.59 ± 0.38A	NA	< 0.001

^A,B,C,DGroups with different letters show significant difference, those with similar letters show no significant difference. HCC: Hepatocellular carcinoma; NA: Not applicable. CH: Chronic hepatitis C.