Difficulties in diagnosing acute kidney injury post liver transplantation using serum creatinine based diagnostic criteria

Table 1 Definitions of acute kidney injury using changes in serum creatinine between the Risk Injury Failure EndStage[7], Akute Kidney Injury Network[8] and Kidney Disease Improving Global Outcomes[9] criteria

Criteria	RIFLE[7]	AKIN[8]	KDIGO[9]
Date of release	2004	2007	2012
Time interval	Diagnosis and Staging: Within 1-7 d and sustained more than 24 h	Diagnosis: Within 48 h Staging: 1 wk	Diagnosis: 50% increase within 7 d or ≥ 0.3 mg/dL (26.5 μmol/L) within 48 h
Stage 1 or R	Increased SCr 1.5-1.9 times baseline	Increased SCr 1.5-1.9 times baseline or ≥ 0.3 mg/dL (≥ 26.5 μmol/L) increase	Increased SCr 1.5-1.9 times baseline (7 d) or ≥ 0.3 mg/dL (≥ 26.5 μmol/L) increase (48 h)
Stage 2 or I	Increased SCr 2.0-2.9 times baseline	Increased SCr 2.0-2.9 times baseline	Increased SCr 2.0-2.9 times baseline
Stage 3 or F	Increased SCr 3.0 times baseline, or Increase in SCr ≥ 4.0 mg/dL (350 μmol/L) with an acute rise of ≥ 0.5 mg/dL (44 μmol/L)	Increased SCr 3.0 times baseline, or Increase in SCr ≥ 4.0 mg/dL (350 μmol/L) with an acute rise of ≥ 0.5 mg/dL (44 μmol/L)	Increased SCr 3.0 times baseline, or Increase in SCr ≥ 4.0 mg/dL (350 μmol/L)

SCr: Serum creatinine; RIFLE: Risk Injury Failure EndStage; AKIN: Akute Kidney Injury Network; KDIGO: Kidney Disease Improving Global Outcomes.