Changes of liver fat content and transaminases in obese children after 12-mo nutritional intervention

Table 3 Liver biochemical parameters and lipid profile of the studied population at baseline and at the end of intervention in relation to liver FF, dichotomized at 9%, alues are mean (SD)+ and median

	Baseline (n = 46)		1P value	End of intervention (n = 46)		1P value
	FF < 9% (n = 30)	FF≥9% (n = 16)		FF < 9% (n = 42)	FF≥9% (n = 4)
2AST (UI/L)	26.70 (5.9); 26.00	38.20 (12.3); 40	0.001	29.10 (8.6); 28.50	34.70 (6.4); 33.00	0.015
2ALT (UI/L)	26.50 (7.7); 25.00	50.50 (28.3); 48.50	0.001	30.50 (13.6); 29.00	40.70 (16.1); 40.50	0.015
2γGT (UI/L)	14.40 (5.0); 13.00	18.20 (4.8); 17.50	0.018	15.40 (5.3); 14.50	16.00 (3.7); 15.50	0.092
Triglycerides (mmol/L)	1.14 (0.44); 1.10	1.62 (0.80); 1.38	0.013	0.96 (0.44); 0.89	1.36 (0.45); 1.25	0.090
Total cholesterol (mmol/L)	4.34 (0.69); 4.35	4.48 (0.74); 4.54	0.539	4.22 (0.73); 4.18	5.06 (0.62); 4.98	0.034
HDL cholesterol (mmol/L)	1.23 (0.21); 1.24	1.20 (0.29); 1.17	0.716	1.21 (0.20); 1.24	1.23 (0.36); 1.21	0.950
LDL cholesterol (mmol/L)	2.58 (0.61); 2.58	2.76 (0.56); 2.75	0.348	2.54 (0.63); 2.53	3.21 (0.75); 3.03	0.086
Apo A (g/L)	1.21 (0.01); 1.23	1.29 (0.24); 1.20	0.259	1.29 (0.21); 1.27	1.12 (0.13); 1.12	0.199
Apo B (g/L)	0.71 (0.18); 0.68	0.77 (0.15); 0. 70	0.261	0.65 (0.14); 0.02	0.85 (0.13); 0. 86	0.064

¹Adjusted for age, sex, BMI Z score and duration of obesity;

²Significance of difference between FF groups (Student’s t test for unpaired data or the Mann-Whitney U test). SI convertion factors: to convert cholesterol, divide values by 0.0259; to convert triglycerides, divide values by 0.0113; to convert Apo A1 and Apo B values by 0.01. Normal range[32]: ALT [5-45 UI/L] for age 1-19 years; AST [15-55 UI/L] for age 1-9 years and [5-45 UI/L] for age 10-19 years; gammaGT [5-32 U/I] for age 4 mo-9 years and [5-24 UI/L] for age 10-15 years[32]. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; γGT: Gamma glutamyltransferase; HDL: High-density-lipoprotein; LDL: Low-density-lipoprotein.