Hepatitis C genotype 6: A concise review and response-guided therapy proposal

Table 1 Prevalence of hepatitis C virus genotype 6 in Asia

Country of origin	Population	Genotyping method	Prevalence of HCV genotype 6	Author
Thailand	n = 236; Blood donors throughout the country	Reverse hybridization	18.0%	Kanisanon et al[7]
	n = 58; Volunteers from four hospitals located in the North, North-east, South and Center of the country	Core sequencing	8.9%	Sunanchaikarn et al[8]
	n = 126; Blood donors in the Northern Thailand	Core sequencing	31.0%	Jutavigittum et al[9]
	n = 375; Blood donors in the Central Thailand	Core and NS5B sequencing	18.9%	Akkarathamrongsin et al[10]
	n = 40; Immigrant workers from Cambodia (n = 25) and Myanmar (n = 15) in Thailand	Core and NS5B sequencing	56% among Cambodian workers and 26.7% among Myanmar workers	Akkarathamrongsin et al[23]
Myanmar	n = 110; Blood donors in Yangon and its suburbs	NS5B sequencing	20.9%	Shinji et al[11]
	n = 145; Volunteers from four different border cities of Myanmar	Core sequencing	49% (Genotype 6 was mostly found in the Northern cities)	Lwin et al[12]
Vietnam	n = 308; Patients from urban community-based GI practice in Southern Vietnam	Core sequencing	31.5%	Nguyen et al[13]
	n = 135; Blood donors in Hanoi (Northern Vietnam	Core (n = 70) and NS5B (n = 65) sequencing	45.9%	Pham et al[14]
Lao PDRHong Kong	n = 45; Blood donors in Lao PDR	Core and NS5B sequencing	95.6%	Hübschen et al[22]
	n = 1055; 949 non-IVDU and 106 IVDU from all over Hong Kong	Core sequencing	27.1% (23.6% among non-IVDU and 58.5% among IVDU)	Zhou et al[26]
	n = 212; Blood donors	NA	27%	Prescott et al[25]
China	n = 148; Patients from nine regions in China	Core and NS5B sequencing	13% (Genotype 6 was only observed in the South)	Lu et al[24]

Source: Ref. [6], with permission. IVDU: Intravenous drug users; NA: Not available; HCV: Hepatitis C virus; GI: Gastrointestinal; PDR: People's Democratic Republic; NA: Not available.