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World J Hepatol. Sep 27, 2013; 5(9): 479-486
Published online Sep 27, 2013. doi: 10.4254/wjh.v5.i9.479
Published online Sep 27, 2013. doi: 10.4254/wjh.v5.i9.479
miRNA | Expression1 | Target genes | Function |
MiRNAs that facilitates HCV infection | |||
miR-122 | Up | 5’ UTR in HCV genome | Promote HCV replication[16-18] and IRES mediated HCV translation[21] |
Xrn1 | Inhibit 5’decay of HCV RNA[22] | ||
Cyclin G1 | Promote Alcohol induced viral replication[27] | ||
SOCS3 | Enhance methylation at SOCS3 gene promoter, inhibits IFN-induced ISRE activity[41] | ||
miR-130a | Up | IFITM1 | Inhibits type 1 IFN signaling pathway and promotes HCV replication[33] |
miR-141 | Up | DLC-1 | Promote viral replication[40] |
miR-21 | Up | MyD88 and IRAK1 | Negatively regulate IFN signaling[42] |
MiRNAs that suppresses HCV infection | |||
miR-448 | Unknown | Core region in HCV genome | Inhibits viral replication[28] |
miR-196/196a | Unknown | NS5A region in HCV genome | Inhibits viral replication[28] |
Bach1 | Inhibits HCV RNA and NS5A protein expression, relieve oxidative stress by upregulating HMOX1 gene expression[31] | ||
let-7b | Unknown | NS5B and 5’UTR regions in HCV genome | Reduces HCV infectivity[29] |
miR-199a | Unknown | 5’ UTR in HCV genome | Inhibits viral replication[30] |
miR-27a | Up | RXRα and ABCA1 | Regulates lipid metabolism, decrease viral infectivity[38] |
MiRNAs that promote inflammation and fibrosis upon HCV infection | |||
miR-449a | Down | NOTCH1 | Regulates YKL40 promoter activity and promotes inflammation[47] |
miR-21 | Up | SMAD7 | Increase TGF-β signaling and promote fibrosis[50] |
miR-29 | Down | COL1A1, COL3A1 | Potentiate fibrosis by activating hepatic stellate cells[32] |
miR-155 | Up | APC | Promote cell proliferation by activating Wnt/β-Catenin signaling pathway[48] |
- Citation: Shrivastava S, Mukherjee A, Ray RB. Hepatitis C virus infection, microRNA and liver disease progression. World J Hepatol 2013; 5(9): 479-486
- URL: https://www.wjgnet.com/1948-5182/full/v5/i9/479.htm
- DOI: https://dx.doi.org/10.4254/wjh.v5.i9.479