Noninvasive assessment of liver damage in chronic hepatitis B

Table 2 Between group comparisons and logistic regression results in chronic hepatitis B patients according to fibrosis stage

Variable	Between group comparisons			Logistic regression analysis
	No/mild fibrosis (n = 34)	Significant fibrosis (n = 55)	P value	Univariate OR (95%CI)	Multivariate OR (95%CI)
Gender (female/male)	16 (47.1)/18 (52.9)	23 (41.8) /32 (58.2)	0.792	1.2 (0.5-2.9)	-
Age (yr)	40.2 ± 11.7	42.2 ± 13.7	0.473	1.01 (0.9-1.05)	-
HGB	14.4 ± 2.08	14.6 ± 1.8	0.735	1.04 (0.8-1.3)	-
Platelet Count (103μL)	203 (176-232)	171 (115-227)	0.010	0.9 (0.9-1)	0.9 (0.9-1)
INR	1.07 ± 0.1	1.13 ± 0.1	0.045	34.5 (1.01-1183.1)	-
Albumine	4.06 ± 0.3	4.01 ± 0.3	0.466	0.6 (0.1-2.3)	-
Total bilirubin (mg/dL)	0.7 (0.5-0.9)	0.8 (0.6-1.1)	0.110	3.05 (0.8-10.8)	-
AST (IU/L)	41.5 (27-73)	47 (32-68)	0.447	1 (0.9-1.01)	-
ALT (IU/L)	57 (33-132)	54 (36-106)	0.866	1 (0.9-1.01)	-
AP (IU/L)	71.5 (62-89)	73 (61-100)	0.630	1.01 (0.9-1.02)	-
GGT (IU/L)	27 (19-48)	36 (23-52)	0.119	1.01 (0.9-1.03)	-
HBV DNA	346 (1.9-1000)	75.7 (1.8-1000)	0.838	1 (0.9-1.01)	-
HBeAg (negative/positive)	30 (88.2)/4 (11.8)	45 (81.8)/10 (18.2)	0.611	1.6 (0.4-5.8)	-
Neutrophil count	3.2 (2.7-4.8)	3.5 (3.04-4.7)	0.569	0.9 (0.6-1.2)	-
Lymphocyte count	1.9 (1.4-2.3)	2 (1.6-2.4)	0.630	0.9 (0.5-1.7)	-
N/L	1.9 (1.3-2.5)	1.8 (1.5-2.2)	0.859	0.8 (0.5-1.3)	-
APRI score	0.5 (0.3-0.9)	0.7 (0.3-1.4)	0.060	1.2 (0.7-2.1)	-

Values are expressed as n (%), mean ± SD or median(25^th-75^th percentiles). HGB: Hemoglobin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; AP: Alkaline phosphatase; GGT: Gamma glutamyl transferase; HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen; N/L: Neutrophil-lymphocyte ratio; APRI: Aspartate aminotransferase/platelet ratio index.