Effect of dichloromethylene diphosphonate on liver regeneration following thioacetamide-induced necrosis in rats

Figure 1 Enzymatic activity after dichloromethylene diphosphonate pre-treatment in rats intoxicated with one sublethal dose of thioacetamide. A: Effect of dichloromethylene diphosphonate (DMDP) pre-treatment on aspartate aminotransferase (AST) activity in the serum of rats intoxicated with one sublethal dose of thioacetamide (TA); B: Illustrates the effect of DMDP pre-treatment on isocitrate dehydrogenase activity in the serum of rats intoxicated with one sublethal dose of TA. Samples were obtained at 0, 12, 24, 48 and 72 h following TA 6.6 mmol (per 500 mg/kg body weight). The results, expressed as nmol per min per mL of serum, are the mean ± SD of four determinations in duplicate from four rats. ^aP < 0.05 vs the respective control, ^cP < 0.05 vs differences due to DMDP.