Herbalife hepatotoxicity: Evaluation of cases with positive reexposure tests

Table 2 Overview of known information of eight cases with suspected Herbalife hepatotoxicity and positive reexposure tests

Presented information	Cases	Individual cases
Daily dose	0/8	-
Exact date of Herbalife start	0/8	-
Exact date of Herbalife end	0/8	-
Exact date of symptoms	0/8	-
Time on Herbalife	8/8	1, 2, 3, 4, 5, 6, 7, 8
Time to onset	8/8	1, 2, 3, 4, 5, 6, 7, 8
Temporal association	7/8	1, 2, 3, 4, 6, 7, 8
Specific symptoms	3/8	1, 5, 6
ALT value	5/8	1, 5, 6, 7, 8
AST value	4/8	1, 5, 7, 8
ALP value	5/8	1, 5, 6, 7, 8
ALT dechallenge	3/8	1, 7, 8
ALT normalization	1/8	1
Hepatobiliary tract imaging	5/8	1, 2, 3, 4, 5
HAV	5/8	1, 2, 3, 4, 5
HBV	5/8	1, 2, 3, 4, 5
HCV	5/8	1, 2, 3, 4, 5
HEV	1/8	5
CMV	4/8	1, 2, 3, 4
EBV	4/8	1, 2, 3, 4
HSV	0/8	-
VZV	0/8	-
Drug comedication	5/8	1, 2, 3, 4, 6
Herbal comedication	2/8	6, 8
Liver histology	3/8	1, 3, 5

Data are derived from the eight cases with details described in Table 1. Time to onset indicates time to symptoms, alternatively to abnormal liver tests. Alanine aminotransferase (ALT) dechallenge and ALT normalization refers only to cases with presented actual ALT values. ALP: Alkaline phosphatase; AMA: Antimitochondrial antibodies; ANA: Antinuclear antibodies; AST: Aspartate aminotransferase; BMI: Body mass index in kg/m²; CIOMS: Council for International Organizations of Medical Sciences; CMV: Cytomegalovirus; EBV: Epstein Barr virus; HAV: Hepatitis A virus; HBV: Hepatitis B virus; HCV: Hepatitis C virus; HEV: Hepatitis E virus; HSV: Herpes simplex virus; VZV: Varicella zoster virus.