Prevalence and risk factors of methotrexate hepatoxicity in Asian patients with psoriasis

Table 3 Risk factors analysis for fibrosis and progression of Roenigk grades n (%)

Risk factor	Proportion of patients with fibrosis	P value1	Proportion of patients with progression	P value1
Gender (male vs female)	4/42 (9.5) vs 3/17 (17.6)	0.382	5/9 (55.6) vs 4/17 (23.5)	0.102
Ethnicity (Chinese vs non-Chinese)	4/39 (10.3) vs 3/20 (15)	0.594	3/16 (18.8) vs 6/10 (60)	0.031
Diabetes mellitus (yes vs no)	5/15 (33) vs 2/44 (4.4)	0.008	4/5 (80) vs 5/21 (23.8)	0.018
Hyperlipidemia (yes vs no)	1/9 (11.1) vs 6/50 (11.7)	> 0.99	3/3 (100) vs 6/23 (26.1)	0.011
Hypertension (yes vs no)	5/15 (33) vs 2/44 (4.4)	0.008	4/6 (66.7) vs 5/20 (25)	0.060
Alcohol consumption (yes vs no)	0/5 (0) vs 7/54 (12.7)	> 0.99	0/2 (0) vs 9/24 (37.5)	0.284

¹Comparison made with Fisher’s Exact Test.