Lymphocyte subsets in alcoholic liver disease

Table 4 Clinical and laboratory comparison between alcoholic liver disease cases with cirrhosis but no active alcoholism and controls

	Patients (n== = 11)	Controls (n = 27)	P value
Age (yr)	56.8 ± 9.0	47.4 ± 14.4	0.03
Men (%)	100	14.8	<0.0001
MELD score	10.5 ± 4.6	-
WBC (× 109/L)	5.4 ± 2.5	6.1 ± 1.4	NS
Neutrophils (× 109/L)	3.4 ± 2.0	3.4 ± 1.2	NS
RBC (× 1012/L)	4.5 ± 0.4	4.5 ± 0.4	0.005
Hemoglobin (g/L)	12.9 ± 2.1	13.9 ± 1.2	NS
MCV (fL)	97.0 ± 6.0	90.8 ± 4.0	0.001
Platelets (× 109/L)	103.5 ± 39.4	231.0 ± 36.0	<0.0001
INR	1.4 ± 0.3	1.0 ± 0.1	<0.0001
Creatinin (mg/dL)	0.9 ± 0.3	0.8 ± 0.1	NS
Albumin (g/dL)	3.4 ± 0.7	3.9 ± 0.6	0.003
Albumin/globulin ratio	0.9 ± 0.3	1.4 ± 0.3	<0.0001
Alkaline phosphatase (UI/dL)	124.9 ± 32.6	68.3 ± 14.0	NS
GGT (UI/dL)	84.2 ± 55.5	37.9 ± 33.1	0.005
ALT (UI/dL)	32.6 ± 7.6	29.4 ± 15.3	NS
AST (UI/dL)	46.9 ± 10.9	25.1 ± 7.9	<0.0001
Total bilirubin (mg/dL)	2.2 ± 2.0	0.7 ± 0.3	<0.0001
CRP (mg/dL)	1.1 ± 1.5	0.7 ± 0.7	NS
Lymphocyte Subsets
Lymphocytes (×109/L)	1.3 ± 0.6	2.1 ± 0.5	<0.0001
CD3+ lymphocytes (/mm3)	954.5 ± 547.4	1523.0 ± 364.6	0.003
CD4+ lymphocytes (/mm3)	745.2 ± 389.0	992.4 ± 274.7	0.032
CD8+ lymphocytes (/mm3)	233.9 ± 120.0	478.9 ± 164.6	<0.0001
CD4+/CD8+ ratio	3.5 ± 1.3	2.3 ± 0.9	0.01
CD19+ lymphocytes (/mm3)	150.8 ± 108.4	264.6 ± 88.0	0.001
NK lymphocytes (/mm3)	99.5 ± 54.5	178.7 ± 210.0	NS

MELD: Model for end-stage liver disease; WBC: White blood cell; RBC: Right blood cell; MCV: Mean cell volume; INR: International normalized ratio; GGT: γ-glutamyl transpeptidase; ALT: Alanine aminotransferase; AST: Aspartate transaminase; CRP: C-reactive protein; NK: Natural killer; NS: Not significant.