Outcomes following liver transplantation in intensive care unit patients

Table 4 Associations of patient and donor characteristics with graft survival (graft loss or death endpoint) and patient survival (death endpoint) in intensive care unit patients

	Association with graft survival (graft loss or death endpoint)		Association with patient survival (death endpoint)
Variable	Relative risk (95%CI)	P value	Relative risk (95%CI)	P value
Patient characteristics
Age at transplant (10 yr increase)	0.98 (0.49-1.99)	0.96	1.00 (0.47-2.11)	0.99
Gender (male)	1.33 (0.42-4.19)	0.63	1.10 (0.34-3.61)	0.88
BMI (10 unit increase)	0.63 (0.24-1.66)	0.35	0.57 (0.20-1.59)	0.28
Diagnosis
Hepatitis C	0.99 (0.32-3.08)	0.99	0.79 (0.24-2.59)	0.69
ETOH	0.57 (0.12-2.59)	0.46	0.65 (0.14-3.02)	0.58
Cryptogenic cirrhosis	3.29 (0.97-11.15)	0.056	3.97 (1.14-13.87)	0.031
MELD at transplant (5 unit increase)	0.99 (0.63-1.57)	0.97	1.09 (0.68-1.75)	0.72
MELD at ICU admission (5 unit increase)	0.85 (0.56-1.30)	0.47	1.03 (0.66-1.61)	0.89
Previous operation	1.07 (0.31-3.67)	0.91	0.76 (0.20-2.95)	0.69
Vasopressors	1.06 (0.32-3.51)	0.93	1.24 (0.36-4.23)	0.74
Vasopressin	0.78 (0.23-2.59)	0.68	0.91 (0.27-3.11)	0.88
Norepinephrine	0.29 (0.04-2.22)	0.23	0.32 (0.04-2.51)	0.28
Vasopressin and norepinephrine	0.44 (0.06-3.44)	0.44	0.50 (0.06-3.90)	0.51
Length of time from hospital admission to ICU admission (doubling)	0.91 (0.64-1.28)	0.57	0.88 (0.61-1.27)	0.49
Ambulation	1.30 (0.36-4.72)	0.69	1.30 (0.36-4.72)	0.69
Dialysis	1.70 (0.46-6.32)	0.43	1.46 (0.38-5.54)	0.58
Tracheostomy	1.00 (0.27-3.71)	1.00	0.61 (0.13-2.83)	0.53
Mechanical ventilation	0.91 (0.29-2.88)	0.88	0.69 (0.20-2.37)	0.56
Donor characteristics
Age (10 yr increase)	0.97 (0.67-1.41)	0.88	0.91 (0.61-1.36)	0.65
Gender (male)	0.74 (0.21-2.63)	0.64	0.52 (0.13-2.09)	0.36
Recipient-donor gender incompatibility	1.33 (0.36-4.91)	0.67	1.76 (0.45-6.87)	0.41
Donation after cardiac death	3.38 (0.95-12.05)	0.060	4.19 (1.12-15.70)	0.033
Donor risk index (1 unit increase)	2.15 (0.54-8.62)	0.28	1.61 (0.36-7.15)	0.53

Relative risks and P values result from single variables Cox proportional hazards regression models. Relative risks correspond to presence of the given characteristic (categorical variables) or the increase given in parenthesis (numerical variables). A higher relative risk indicates an increased likelihood of experiencing the given endpoint. ICU: Intensive care unit; BMI: Body mass index; ETOH: Ethanol; MELD: Model for end-stage liver disease..