Centrilobular necrosis in acute presentation of Japanese patients with type 1 autoimmune hepatitis

Table 1 Clinicopathological data of patients with autoimmune hepatitiswith and without centrilobular necrosis n (%)

Abbreviations (normal values)	With CN (n = 13)	Without CN (n = 28)	P value
Mean age (range) (yr)	51.1 (23-80)	52.7 (21-77)	NS
Sex (M/F)	2/11	1/27	NS
ALT (IU/L)	907 (228-3250)	667 (224-1761)	NS
ALP (IU/L)	498 (223-999)	450 (76-883)	NS
IgG (mg/dL)	2307 (1150-3913)	3126 (1294-5449)	< 0.05
ANA neg.	4 (30.7)	1 (3.5)	< 0.05
Other autoimmune disease	4 (30.7)	7 (25.0)	NS
Steroid therapy	11 (84.6)	24 (85.7)	NS
Azathioprine therapy	2 (15.4)	7 (25.0)	NS
AIH score original	12 (6-20)	14 (6-18)	NS
(Median) simplified	6 (3-8)	7 (5-8)	< 0.05
Interface hepatitis	10 (76.9)	26 (92.8)	NS
Portal inflammation	13 (100)	24 (85.7)	NS
Plasma cell infiltration	7 (53.8)	7 (25.0)	NS
Rosette formation	3 (23.1)	3 (12.0)	NS
Fibrosis
Stage F0-2	11 (84.6)	10 (35.7)	< 0.05
Stage F3-4	2 (15.4)	18 (64.3)

ALT: Alanineaminotransferase (8-42 IU/L); ALP: Alkaline phosphatase (115-359 IU/L); IgG: Immunoglobulin G (870-1700 mg/dL); ANA: Antinuclear antibody (< 40 ×); NS: Not significant; AIH: Autoimmune hepatitis; CN: Centrilobular necrosis. P values were calculated using the Mann-Whitney U test and the χ² test.