Hepatocellular carcinoma and focal nodular hyperplasia of the liver in a glycogen storage disease patient

Figure 6 Giant tumor in the right lobe. A: Resected specimen showed a giant tumor of 10 cm in diameter on the cut surface. The tumor contained septums and hemorrhagic regions; B: hematoxylin and eosin stain (HE) staining revealed the capsule with some extracapsular invasions (HE × 4); C: Histology of the tumor revealed moderately differentiated hepatocellular carcinoma with intrahepatic metastases, whereas no adenomatous components were observed (HE × 400); D: Cells with enlarged clear endoplasmic reticula were observed in the non-tumorous region [periodic acid-Schiff (PAS) stain × 4]. E: PAS staining revealed a PAS-positive area in accordance with a clear area (PAS × 400).