G6PT-H6PDH-11βHSD1 triad in the liver and its implication in the pathomechanism of the metabolic syndrome

Figure 1 The glucose-6-phosphate transporter - hexose-6-phosphate dehydrogenase - 11β-hydroxysteroid dehydrogenase type 1 triad. Local glucocorticoid activation is catalyzed by a triad of the endoplasmic reticulum, composed by glucose-6-phosphate-transporter, hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase type 1. The role of their cooperation is the enhancement of local glucocorticoid effect. PPP: pentose phosphate pathway; G6PT: Glucose-6-phosphate transporter; H6PDH: Hexose-6-phosphate dehydrogenase; 11βHSD1: 11β-hydroxysteroid dehydrogenase type 1; NADP: Nicotinamide adenine dinucleotide phosphate; ER: Endoplasmic reticulum.