Efficacy of 3 years of adefovir monotherapy in chronic hepatitis B patients with lamivudine resistance

doi:10.4254/wjh.v4.i12.389

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Dec 27, 2012; 4(12): 389-393
Published online Dec 27, 2012. doi: 10.4254/wjh.v4.i12.389

Table 2 Control of the therapeutic effect in the two groups

Group	Baseline	n	12 wk		24 wk		52 wk		104 wk		156 wk
Group	(copies/mL)	n	VR¹	BR²	VR¹	BR²	VR¹	BR²	VR¹	BR²	VR¹	BR²
A	10³-10⁵	18	16 (88.8)¹	16 (88.8)	16 (88.8)¹	16 (88.8)	16 (88.8)³	16 (88.8)	16 (88.8)¹	16 (88.8)	16 (88.8)¹	16 (88.8)
A	≥ 10⁶	34	14 (41.1)	24 (70.5)	15 (44.1)	30 (88.2)	16 (47.0)	22 (64.7)	16 (47.0)	26 (76.4)	16 (47.0)	18 (52.9)
B	10³-10⁵	11	9 (81.8)⁴	9 (81.8)	9 (81.8)⁴	10 (90.9)	9 (81.8)⁴	10 (90.9)	8 (72.7)	9 (81.8)	9 (81.8)⁴	9 (81.8)
B	≥ 10⁶	13	6 (46.1)	10 (76.9)	6 (46.1)	10 (76.9)	6 (46.1)	9 (69.2)	7 (53.8)	9 (69.2)	6 (46.1)	9 (69.2)

A	HBeAg positive	36	18 (50.0)	26 (72.2)	20 (55.5)	30 (83.3)	20 (55.5)	26 (72.2)	22 (61.1)	26 (72.2)	20 (55.5)	22 (61.1)
A	HBeAg negative	16	12 (75.0)	14 (87.5)	14 (87.5)	16 (100.0)	12 (75.0)	12 (75.0)	14 (87.5)	16 (100.0)	12 (75.0)	6 (75.0)
B	HBeAg positive	17	8 (47.8)	12 (70.5)	9 (52.9)	15 (88.2)	9 (52.9)	15 (88.2)	9 (52.9)	13 (76.4 )	10 (58.8)	11 (64.7)
B	HBeAg negative	7	5 (71.4)	6 (85.7)	5 (71.4)	6 (85.7)	6 (85.7)	6 (85.7)	5 (71.4)	6 (85.7)	5 (71.4)	6 (85.7)

A	ALT < 2 × ULN	20	17 (85.0)	18 (90.0)	16 (80.0)	18 (90.0)	14 (70.0)	14 (70.0)	14 (70.0)	18 (90.0)	14 (70.0)	14 (70.0)
A	ALT > 2 × ULN	32	18 (56.2)	22 (68.7)	18 (56.2)	28 (87.5)	18 (56.2)	26 (81.2)	22 (68.7)	24 (75.0)	18 (56.25)	20 (62.5)
B	ALT < 2 × ULN	10	8 (80.00)	9 (90.0)	8 (80.0)	10 (100.0)	8 (80.0)	10 (100.0)	8 (80.0)	10 (100.0)	8 (80.0)	9 (90.0)
B	ALT > 2 × ULN	14	8 (57.1)	10 (71.4)	8 (57.1)	12 (85.7)	10 (71.4)	12 (85.7)	10 (71.4)	12 (85.7)	10 ( (71.4)	12 (85.7)

Group A: Treated with adefovir; Group B: Treated with adefovir and lamivudine;

¹VR: Defined as HBV DNA < lower detection limit;

²BR: Defined as ALT < lower detection limit;

³P < 0.01 (χ² = 4.35-5.4) vs group A with baseline HBV DNA ≥ 10⁶ copies/mL;

⁴P < 0.05 (χ² = 4.1-5.0) vs group B with baseline HBV DNA ≥ 10⁶ copies/mL. VR: Virological response; BR: Biochemical response; HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen; ALT: Alanine aminotransferase.

Citation: Song MN, Hong MZ, Luo DQ, Huang WQ, Min F, Fan RH, Wu WB, Zhang L. Efficacy of 3 years of adefovir monotherapy in chronic hepatitis B patients with lamivudine resistance. World J Hepatol 2012; 4(12): 389-393
URL: https://www.wjgnet.com/1948-5182/full/v4/i12/389.htm
DOI: https://dx.doi.org/10.4254/wjh.v4.i12.389