Is an estimated glomerular filtration rate better than creatinine to be incorporated into the end-stage liver disease score?

Table 2 Univariate and multivariate logistic regression analyses of the various parameters in predicting in-hospital mortality

Parameter	Beta coefficient	Standard error	Odds ratios (95% CI)	P value
Univariate logistic regression analysis
Age, yr	0.02	0.00	1.02 (1.02-1.03)	< 0.001
Hepatoma	0.95	0.07	2.57 (2.25-2.95)	< 0.001
Ascites	1.47	0.07	4.36 (3.80-5.02)	< 0.001
Hepatic encephalopathy	1.29	0.07	3.62 (3.13-4.19)	< 0.001
Cause of liver cirrhosis (reference group: NBNCNA)
Hepatitis C	-0.30	0.10	0.74 (0.61-0.91)	0.004
Hepatitis B	-0.17	0.10	0.85 (0.70-1.03)	NS (0.098)
Alcoholic	-0.76	0.11	0.47 (0.38-0.58)	< 0.001
Hepatitis C + hepatitis B	-0.51	0.22	0.60 (0.39-0.92)	0.020
Hepatitis C + alcoholic	-0.53	0.17	0.59 (0.42-0.82)	0.002
Hepatitis B + alcoholic	-0.15	0.36	0.86 (0.42-1.74)	NS (0.670)
Hepatitis C + hepatitis B + alcoholic	-0.47	0.28	0.63 (0.36-1.09)	NS (0.098)
Child–Pugh points	0.67	0.02	1.95 (1.87-2.03)	< 0.001
MELD score	0.22	0.01	1.25 (1.23-1.27)	< 0.001
BUN, mg/dL	0.07	0.00	1.07 (1.06-1.07)	< 0.001
Creatinine, mg/dL	0.72	0.03	2.05 (1.93-2.18)	< 0.001
eGFR, mL/(min∙1.73 m-2) (MDRD-4)	-0.04	0.00	0.97 (0.96-0.97)	< 0.001
eGFR, mL/(min∙1.73 m-2) (MDRD-6)	-0.05	0.00	0.95 (0.95-0.96)	< 0.001
eGFR, mL/(min∙1.73 m-2) (CKD-EPI)	-0.04	0.00	0.97 (0.96-0.96)	< 0.001
Albumin, g/dL	-1.97	0.07	0.14 (0.12-0.16)	< 0.001
Total bilirubin, mg/dL	0.20	0.01	1.22 (1.20-1.25)	< 0.001
INR	1.74	0.08	5.70 (4.87-6.67)	< 0.001
Multivariate logistic regression analysis
Age, yr	0.03	0.01	1.03 (1.01-1.04)	< 0.001
Hepatoma	0.95	0.13	2.60 (2.02-3.34)	< 0.001
Cause of liver cirrhosis (reference group: NBNCNA)
Hepatitis C	-0.19	0.18	0.83 (0.58-1.18)	NS (0.299)
Hepatitis B	-0.28	0.19	0.76 (0.52-1.10)	NS (0.139)
Alcoholic	-0.21	0.22	0.81 (0.52-1.25)	NS (0.342)
Hepatitis C + hepatitis B	-1.03	0.40	0.36 (0.16-0.78)	0.010
Hepatitis C + alcoholic	-0.79	0.35	0.46 (0.23-0.90)	0.023
Hepatitis B + alcoholic	0.32	0.57	1.38 (0.45-4.22)	NS (0.576)
Hepatitis C + hepatitis B + alcoholic	0.54	0.47	1.71 (0.68-4.29)	NS (0.354)
MELD score	0.14	0.03	1.14 (1.09-1.20)	< 0.001
BUN, mg/dL	0.04	0.00	1.05 (1.04-1.05)	< 0.001
eGFR, mL/(min∙1.73 m-2) (MDRD-4)	0.03	0.01	1.03 (1.02-1.04)	< 0.001
eGFR, mL/(min∙1.73 m-2) (MDRD-6)	-0.03	0.01	0.97 (0.95-0.99)	< 0.001
Albumin, g/dL	-1.24	0.13	0.29 (0.22-0.38)	< 0.001
INR	0.24	0.10	1.27 (1.04-1.54)	0.019

MELD: Model for end-stage liver disease; BUN: Blood urea nitrogen; eGFR: Estimated glomerular filtration rate; MDRD: Modification of diet in renal disease; MDRD-4: 4-variable MDRD; MDRD-6: 6-variable MDRD; CKD-EPI: The chronic kidney disease epidemiology collaboration; INR: International normalized ratio; NS: Not significant.