Is an estimated glomerular filtration rate better than creatinine to be incorporated into the end-stage liver disease score?

doi:10.4254/wjh.v4.i11.291

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Nov 27, 2012 (publication date) through Nov 30, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Nov 27, 2012; 4(11): 291-298
Published online Nov 27, 2012. doi: 10.4254/wjh.v4.i11.291

Table 1 Clinical characteristics, demographic data and laboratory data of 3857 cirrhotic patients

Parameter	All patients (n = 3857)	Survivors (n = 2375)	Non-survivors (n = 1482)	P value
Age, yr	60.73 ± 14.05	59.02 ± 14.02	63.48 ± 13.65	< 0.001
Male, n (%)	2665 (69.1)	1651 (69.52)	1014 (68.42)	NS (0.474)
Hepatoma, n (%)	1385 (35.9)	653 (27.5)	732 (49.4)	< 0.001
Cause of liver cirrhosis, n (%)				< 0.001
Hepatitis C	930 (24.1)	568 (23.9)	362 (24.4)	-
Hepatitis B	1090 (28.3)	631 (26.6)	459 (31)	-
Alcoholic	813 (21.1)	580 (24.4)	233 (15.7)	-
Hepatitis C + hepatitis B	106 (2.7)	70 (2.9)	36 (2.4)	-
Hepatitis C + alcohol	60 (1.6)	39 (1.6)	21 (1.4)	-
Hepatitis B + alcohol	191 (5)	127 (5.3)	64 (4.3)	-
Hepatitis C + hepatitis B + alcohol	33 (0.9)	19 (0.8)	14 (0.9)	-
Not hepatitis C, hepatitis B or alcohol	634 (16.4)	341 (14.4)	293 (19.8)	-
Ascites, n (%)	1861 (48.2)	825 (34.7)	1036 (69.9)	< 0.001
Hepatic encephalopathy, n (%)	1097 (28.4)	434 (18.3)	663 (44.7)	< 0.001
Child–Pugh points	8.36 ± 2.57	7.11 ± 1.97	10.37 ± 2.1	< 0.001
MELD score	18.9 ± 10.26	13.15 ± 5.57	27.98 ± 9.36	< 0.001
Albumin, 3.5-5 g/dL	2.95 ± 0.73	3.24 ± 0.68	2.49 ± 0.55	< 0.001
Total bilirubin, 0.3-1.2 mg/dL	5.18 ± 8.16	2.24 ± 3.57	9.89 ± 10.81	< 0.001
INR	1.89 ± 1.75	1.43 ± 0.43	2.72 ± 2.55	< 0.001
BUN, 8-12 mg/dL	34.47 ± 35.55	17.63 ± 15.52	61.44 ± 41.49	< 0.001
Creatinine, 0.4-1.2 mg/dL	1.94 ± 1.91	1.27 ± 1.35	3.01 ± 2.17	< 0.001
eGFR, mL/(min∙1.73 m^-2) (MDRD-4)	63.17 ± 46.12	79.14 ± 37.4	37.57 ± 47.24	< 0.001
eGFR, mL/(min∙1.73 m^-2) (MDRD-6)	54.87 ± 38.25	70.85 ± 33.29	29.32 ± 31.16	< 0.001
eGFR, mL/(min∙1.73 m^-2) (CKD-EPI)	65.39 ± 37.49	82.11 ± 30.28	38.59 ± 31.99	< 0.001

Values were expressed as mean ± SD unless otherwise defined. Statistical comparison was performed with Student’s t and χ² test. MELD: Model for end-stage liver disease; INR: International normalized ratio; BUN: Blood urea nitrogen; eGFR: Estimated glomerular filtration rate; MDRD: Modification of diet in renal disease; MDRD-4: 4-variable MDRD; MDRD-6: 6-variable MDRD; CKD-EPI: The chronic kidney disease epidemiology collaboration; NS: Not significant.

Citation: Chen YW, Chang CW, Chang CW, Wang TE, Wu CJ, Chen HH. Is an estimated glomerular filtration rate better than creatinine to be incorporated into the end-stage liver disease score? World J Hepatol 2012; 4(11): 291-298
URL: https://www.wjgnet.com/1948-5182/full/v4/i11/291.htm
DOI: https://dx.doi.org/10.4254/wjh.v4.i11.291