Nonmuscle myosin II regulates migration but not contraction in rat hepatic stellate cells

doi:10.4254/wjh.v3.i7.184

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Jul 27, 2011 (publication date) through Nov 8, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jul 27, 2011; 3(7): 184-197
Published online Jul 27, 2011. doi: 10.4254/wjh.v3.i7.184

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Figure 5 Effect of nonmuscle myosin II inhibition on hepatic stellate cell migration. Culture-activated hepatic stellate cells (Day 3) were transiently transfected with siRNA targeted to all nonmuscle myosin (NMM) II permutations (NMM II-A, II-B,II-A & II-B) or scramble siRNA and incubated for 48 h. A plate scrape model of migration was used to simulate liver injury. After 24 h, migration was calculated as change in wound (gap) diameter over time. Top panel: representative micrographs. Bottom panel: Migration assay quantification. (^aP < 0.05 as compared to scramble).

Citation: Moore CC, Lakner AM, Yengo CM, Schrum LW. Nonmuscle myosin II regulates migration but not contraction in rat hepatic stellate cells. World J Hepatol 2011; 3(7): 184-197
URL: https://www.wjgnet.com/1948-5182/full/v3/i7/184.htm
DOI: https://dx.doi.org/10.4254/wjh.v3.i7.184