MELD score, insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease

doi:10.4254/wjh.v3.i6.157

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jun 27, 2011; 3(6): 157-163
Published online Jun 27, 2011. doi: 10.4254/wjh.v3.i6.157

Table 5 Clinical and biochemical parameters ranked by severity of bone loss

	Normal	Osteopenia	Osteoporosis	P value
BMI	26.8 (5.1)	24.4 (5.1)^a	22.9 (3.6)^a	0.006
MELD	15.5 (5.9)	14.2 (5.7)	16.9 (6.5)	0.18
25OHD	33.9 (15.7)	33.4 (20.2)	27.9 (15.3)	0.25
Testosterone	11.1 (9.8)	13.7 (10.8)	10.1 (8.3)	0.41
IGF-1	38.3 (35.5)	44.4 (67.5)	39.2 (46.1)	0.86
TNFα	14.3 (10.7)	15.2 (7.6)	14.7 (8.0)	0.89
IL-6	11.8 (12.9)	12.4 (14.0)	15.6 (17.4)	0.64
UNTx	47.2 (27.3)	59.4 (38.7)	70.2 (41.6)^b	0.08

Values are presented as mean (SD);

^aSignificantly lower than in subjects with normal BMD;

^bSignificantly higher than UNTx in subjects with normal BMD (P = 0.027) (Using post-hoc test of ANOVA). BMI: Body mass index; 25OHD: 25-hydroxyvitamin D; IGF-1: Insulin-like growth factor-1; TNFα: Tumor necrosis factor-α; IL-6: Interleukin-6.

Citation: Mitchell R, McDermid J, Ma MM, Chik CL. MELD score, insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease. World J Hepatol 2011; 3(6): 157-163
URL: https://www.wjgnet.com/1948-5182/full/v3/i6/157.htm
DOI: https://dx.doi.org/10.4254/wjh.v3.i6.157