MELD score, insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease

doi:10.4254/wjh.v3.i6.157

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Jun 27, 2011 (publication date) through Nov 22, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jun 27, 2011; 3(6): 157-163
Published online Jun 27, 2011. doi: 10.4254/wjh.v3.i6.157

Table 2 Clinical and Biochemical Data by Etiology of Cirrhosis

Variable	Viral	Alcohol	Cholestasis	Other
Variable	n = 46	n = 20	n = 25	n = 26
BMI (kg/m²)	25.4 (5.1)	24.4 (5.3)	23.3 (3.2)	25.8 (5.9)
MELD score	15.1 (6.14)	16.2 (6.14)	14.2 (5.06)	15.6 (6.51)
Corrected calcium (nmol/L)	2.39 (0.28)	2.44 (0.21)	2.37 (0.11)	2.41 (0.22)
PTH (ng/L)	2.14 (1.2)^a	3.73 (2.7)	2.83 (1.5)	3.48 (3.9)
25OHD (μg/L)	30.6 (16.1)	34.4 (20.1)	37.0 (20.2)	28.7 (17.0)
Testosterone (nmol/L)	12.7 (11.2)	7.0 (4.5)^b	15.7 (7.4)	12.2 (11.5)
IGF-1 (μg/L)	34.5 (47.3)	28.3 (27.1)	45.9 (47.7)	59.5 (79.2)
TNFα (ng/L)	16.1 (10.9)	13.7 (6.7)	15.0 (8.4)	13.0 (5.0)
IL-6 (ng/L)	26.7 (72.4)	19.3 (20.7)	7.1 (5.3)	9.9 (12.2)
UNTx (nmol BCE/mmol creatinine)	54.9 (38.0)	69.3 (25.2)	56.5 (41.6)	53.7 (36.2)

^aPTH significantly lower in viral group than in alcohol and other (P < 0.05);

^bTestosterone significantly lower in alcohol group than in cholestasis (P < 0.05). BCE: bone collagen equivalents; PTH: Parathyroid hormone; BMI: Body mass index; 25OHD: 25-hydroxyvitamin D; IGF-1: Insulin-like growth factor-1; TNFα: Tumor necrosis factor-α; IL-6: Interleukin-6. Values are presented as mean (SD)

Citation: Mitchell R, McDermid J, Ma MM, Chik CL. MELD score, insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease. World J Hepatol 2011; 3(6): 157-163
URL: https://www.wjgnet.com/1948-5182/full/v3/i6/157.htm
DOI: https://dx.doi.org/10.4254/wjh.v3.i6.157