Asymptomatic primary biliary cirrhosis is not associated with increased frequency of cardiovascular disease

Table 3 Characteristics of patients with asymptomatic and symptomatic primary biliary cirrhosis

Variables	Asymtomatic	Symptomatic	P value
	n = 66	n = 114
Age (years)	56.7 (31-74)	56.0 (22-73)	0.4
Female gender	58 (87.9)	107 (93.9)	0.2
Caucasian	60 (90.9)	98 (86)	0.3
AMA	50 (78.1)	87 (77.7)	1
BMI	26.2 (19-43)	27 (17.6-51)	0.4
Hypertension	19 (29.2)	29 (25.4)	0.6
Diabetes	12 (18.5)	14 (12.3)	0.3
Smoking	18 (28.6)	44 (38.6)	0.2
Stage of fibrosisa			0.6
0-2	21 (35.6)	43 (40.2)
3-4	38 (64.4)	64 (59.8)
Total cholesterol (mg/dL)	223.5 (84-2055)	209.5 (81-612)	0.06
LDL (mg/dL)	134 (34-505)	123 (12-539)	0.2
HDL (mg/dL)	57 (17-163)	53 (20-118)	0.5
Triglyceride (mg/dL)	105 (32-527)	104 (32-736)	0.6
Statin use	8 (12.1)	7 (6.1)	0.2
CAD	3 (4.5)	11 (9.6)	0.22
TIA	0	1 (0.9)	1
Stroke	0 (0)	3 (2.6)	0.3
Any CVD	3 (4.5)	15 (13.2)	0.06

PBC: primary biliary cirrhosis; AMA: antimitochondrial antibody; BMI: body mass index; LDL: low density lipoprotein; HDL: high density lipoprotein; CAD: coronary artery disease; TIA: transient ischemic attack; CVD: cardiovascular disease. Continuous variables are expressed as median (range). Categorical variables are expressed as number (frequency).

^aBased on the Metavir scoring system