Polymorphisms in programmed death-1 gene are not associated with chronic HBV infection in Chinese patients

Table 2 The associations between PD-1 gene polymorphism and chronic HBV infection by family-based association test (single-marker FBAT analysis) in additive or dominant or recessive model

Marker	Allele	Additive model			Dominant model			Recessive model
		Familiesa	Zb	P	Familiesa	Zb	P	Familiesa	Zb	P
PD1.1	A	72	-0.265	0.791	42	-0.617	0.537	46	0.193	0.847
	G	72	0.265	0.791	46	-0.193	0.847	42	0.617	0.537
PD1.2	A	79	0.640	0.522	41	-0.080	0.936	53	1.001	0.317
	G	79	-0.640	0.522	53	-1.001	0.317	41	0.080	0.936

^aInformative families: families may have two heterozygote parents or multiple offspring. When the number of informative families is less than 10, the test will not be computed; ^bThe negative sign of Z statistic indicates that the frequency of transmitted allele is negative association with susceptibility of chronic HBV infection. PD-1: pro­grammed death-1; HBV: hepatitis B virus.