Multicentric occurrence of hepatocellular carcinoma with nonalcoholic steatohepatitis

Table 3 Clinical characteristics of patients with solitary hepatocellular carcinoma related to nonalcoholic steatohepatitis in previous and present reports

Author	Cases	Age older than 70 yr	Gender		Metabolic diseases				Histological features
			M	F	OB	DM	DL	HT	LC	Non-LC
Cotrim et al[21]	1	0	1	0	1	1	0	0	1	0
Orikasa et al[22]	1	0	0	1	0	1	0	0	1	0
Shimada et al[23]	4	1	2	2	3	2	1	2	4	0
Mori et al[24]	1	1	1	0	1	1	0	0	1	0
Bullock et al[25]	2	1	2	0	2	2	0	2	0	2
Cuadrado et al[26]	2	1	2	0	2	2	0	0	1	1
Sato et al[27]	1	0	1	0	1	0	1	0	0	1
Ichikawa et al[28]	2	0	1	1	1	0	1	1	0	2
Ikeda et al[29]	1	0	1	0	1	1	0	1	1	0
Hai et al[30]	2	1	2	0	2	2	0	1	1	1
Hashizume et al[31]	7	5	4	3	5	5	6	5	5	2
Maeda et al[32]	3	0	2	1	NA	NA	NA	NA	3	0
Kawada et al[33]	6	4	3	3	2	3	1	4	0	6
Malik et al[34]	8	2	6	2	5	6	NA	5	8	0
Chagas et al[35]	4	3	2	2	4	3	1	NA	4	0
Takuma et al[36]	8	5	4	4	4	6	3	6	3	5
Present authors	3	2	1	2	2	1	2	2	3	0
Total	56	26	35	21	36	36	16	29	36	20
(%)	-	(46.4)	(62.5)	(37.5)	(67.9)	(67.9)	(35.6)	(59.2)	(64.3)	(35.7)

M: male; F: female; OB: obesity; DM: type 2 diabetes mellitus; DL: dyslipidemia; HT: hypertension; NA: not available; LC: liver cirrhosis; Non-LC: non-liver cirrhosis. All values represent number of cases.