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©2010 Baishideng.
World J Hepatol. Mar 27, 2010; 2(3): 114-126
Published online Mar 27, 2010. doi: 10.4254/wjh.v2.i3.114
Published online Mar 27, 2010. doi: 10.4254/wjh.v2.i3.114
Figure 1 The liver cancer initiation hypothesis based on CSCs theory.
The hepatic stem cells (SC) and oval progenitor (OC) cells have specific capacities to self renew and differentiate into multiple hepatic lineages. Mutations in SC and/or OC may modify the cells genetic property and switch the normal SC into CSCs leading to tumor initiation.
- Citation: Sukowati CH, Rosso N, Crocè LS, Tiribelli C. Hepatic cancer stem cells and drug resistance: Relevance in targeted therapies for hepatocellular carcinoma. World J Hepatol 2010; 2(3): 114-126
- URL: https://www.wjgnet.com/1948-5182/full/v2/i3/114.htm
- DOI: https://dx.doi.org/10.4254/wjh.v2.i3.114