Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma

Figure 3 Immunohistochemical staining for Rb1/p105 in liver sections of the control group patients as well as HCV-infected patients and HCV-related HCC patients. A: Liver section from a case of the control showing negative staining for Rb1/p105 either in the cytoplasm or in the nuclei of hepatocytes (IP × 20); B: Liver section from a case with CHC showing moderate nuclear expression for Rb1/p105 in the hepatocytes (long arrow) and in few scattered inflammatory cells (short arrow) of the portal tract (IP × 40); C: Liver section from a case with LC showing moderate nuclear expression for Rb1/p105 in hepatocytes (arrows) and some inflammatory cells of the portal tract in LC (IP × 20); D: Liver section from a case with poorly-differentiated HCC showing marked nuclear expression for Rb1/p105 in the hepatocytes (arrows) (IP × 40).