Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma

Figure 1 Immunohistochemical staining for Cyclin D1 in liver sections of patients from the control group as well as HCV-infected patients and HCV-related HCC patients. A: Liver section from a control case showing mild nuclear staining for Cyclin D1 (arrows) (Immunoperoxidase × 40); B: Liver section from a case of CHC showing mild nuclear expression of Cyclin D1 (arrows). The portal tract is completely free from immunostaining (Immunoperoxidase × 40); C: Liver section from a case of LC showing moderate number of positively stained hepatocytes in a cirrhotic nodule (arrows) (Immunoperoxidase × 40); D: Liver section from a case of poorly-differentiated HCC showing marked nuclear expression of Cyclin D1 (arrows) (Immunoperoxidase × 40).