Minimizing liver uptake of cationic 99mTc radiotracers with ether and crown ether functional groups

Figure 7 SPECT images of the same dog (with acute myocardial infarction) administered with ~10 mCi of ^99mTc-Sestamibi and ^99mTcN-MPO at 30 and 60 min p. i. Arrows indicate the presence of perfusion defects due to myocardial infarction. For ^99mTcN-MPO, the perfusion defects were clearly seen as early as 30 min post-injection due to its fast liver clearance. For ^99mTc-Sestamibi, there was a significant between the perfusion defects and the liver radioactivity.