Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma

Table 6 Immunohistochemical reactivity for Rb/p105 in all studied cases (mean ± SE) n(%)

Groups n = 125	Staining pattern	Positive expression	Immunohistochemical reactivity			Hepatic expression
			Mild	Moderate	Marked
			(1%-30%)	(31%-60%)	(61%-100%)
Control (n = 15)	Negative	0 (0)	0 (0)	0 (0)	0 (0)	0.00 ± 0.00
CHC without cirrhosis (n = 50)	Nuclear	30 (60.0)	27 (90.0)	3 (10.0)	0 (0)	28.7 ± .1
CHC with cirrhosis (n = 30)	Nuclear	15 (50.0)	5 (33.3)	10 (66.7)	0 (0)	40.9 ± 2.8a
HCV-related HCC (n = 30)	Nuclear	21 (70.0)	0 (0)	12 (57.1)	9 (42.9)	61 ± 3.7ab
Well-differentiated HCC (n = 15)	Nuclear	12 (80.0)	0 (0)	12 (100)	0 (0)	67.3 ± 4.8ab
Poorly-differentiated HCC (n = 15)	Nuclear	9 (60.0)	0 (0)	0 (0)	9 (100)	55.7 ± 1.4abc

^aP < 0.01 vs CHC without cirrhosis;

^bP < 0.001 vs LC;

^cP < 0.01 vs well-differentiated carcinoma.