Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma

Table 5 Immunohistochemical reactivity for p27 in all studied cases (mean ± SE) n(%)

Groups n = 125	Staining pattern	Immunohistochemical reactivity		Hepatic expression
		Weak (< 50%)	Marked (> 50%)
Control (n = 15)	Nuclear/mixed	9 (60.0)	6 (40.0)	44.4 ± 1.9
CHC without cirrhosis (n = 50)	Nuclear/cytoplasmic	5 (10.0)	45 (90.0)	59.8 ± 1.9a
CHC with cirrhosis (n = 30)	Nuclear/mixed	0 (0)	30 (100)	65.9 ± 1.6a
HCV-related HCC (n = 30)	Nuclear/mixed	21 (70.0)	9 (30.0)	34.1 ± 2.7abc
Well-differentiated HCC (n = 15)	Nuclear	7 (46.7)	8 (53.3)	36.2 ± 5.2abc
Poorly-differentiated HCC (n = 15)	Mixed	15 (100)	0 (0)	32.0 ± 1.7abc

^aP < 0.01 vs controls;

^bP < 0.001 vs CHC without cirrhosis;

^cP < 0.001 vs LC.