Correlation between the interleukin-36 subfamily and gut microbiota in patients with liver cirrhosis: Implications for gut-liver axis imbalance

Table 2 Analysis of the correlation between serum interleukin-36 subfamily cytokines and clinical indicators in study participants

Variables	IL-36α		IL-36γ		IL-36Ra		IL-38
	R value	P value	R value	P value	R value	P value	R value	P value
WBC (109/L)	0.005	0.963	0.047	0.661	-0.111	0.298	0.048	0.655
HB (g/L)	-0.296	0.005	-0.245	0.020	-0.240	0.023	-0.186	0.079
PLT (109/L)	-0.345	0.001	-0.275	0.009	-0.255	0.015	-0.153	0.151
Alb (g/L)	0.525	< 0.001	-0.437	< 0.001	-0.185	0.082	-0.346	0.001
ALT (U/L)	0.180	0.090	-0.187	0.077	-0.020	0.852	0.165	0.119
AST (U/L)	0.395	< 0.001	0.584	< 0.001	0.172	0.104	0.495	< 0.001
ALP (U/L)	0.482	< 0.001	0.354	< 0.001	0.136	0.202	0.406	< 0.001
γ-GGT (U/L)	0.437	< 0.001	-0.023	0.828	0.036	0.736	-0.043	0.689
TBIL (umol/L)	0.471	< 0.001	0.559	< 0.001	0.228	0.031	0.540	< 0.001
Cr (umol/L)	-0.080	0.451	-0.024	0.823	-0.187	0.078	0.003	0.981
Child-pug score	0.418	0.001	0.387	0.002	0.203	0.117	0.380	0.003

IL: Interleukin; HB: Hemoglobin; PLT: Blood platelet; Alb: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; γ-GGT: Gamma-glutamyltransferase; TBIL: Total bilirubin; Cr: Creatinine; WBC: White blood cell.