Establish and validate an artificial neural networks model used for predicting portal vein thrombosis risk in hepatitis B-related cirrhosis patients

Table 2 Factors associated with prediction incidence of portal vein thrombosis

Variables	Univariate analysis		P value
	β	HR (95%CI)
Age (year)	0.044	1.045 (1.029-1.061)	< 0.001
Sex (male)	0.267	1.306 (0.873-1.954)	0.194
Smoking	0.081	0.922 (0.605-1.405)	0.706
Alcohol consumption	0.161	1,175 (0.767-1.800)	0.458
Diabetes	0.255	1.291 (0.807-2.064)	0.287
Ascites	0.660	1.935 (1.354-2.766)	< 0.001
Hepatic encephalopathy	0.255	1.291 (0.807-2.064)	0.287
Gastrointestinal varices with bleeding	0.767	2.153 (1.420-3.265)	< 0.001
Alanine aminotransferase (U/L)	-0.002	0.998 (0.996-0.999)	0.004
Aspartate aminotransferase (U/L)	-0.002	0.998 (0.996-0.999)	0.323
Total bilirubin (mg/dL)	-0.003	0.997 (0.992-1.001)	0.114
Albumin (g/L)	-0.029	0.972 (0.947-0.997)	0.028
gamma-glutamyl transpeptidase (U/L)	0.001	1.001 (0.998-1.003)	0.637
White blood cell count (× 109/L)	-0.007	0.993 (0.913-1.079)	0.861
NLR	0.286	1.331 (1.262-1.403)	< 0.001
Platelets (× 109/L)	-0.022	0.979 (0.972-0.985)	< 0.001
Creatinine (μmol/L)	0.001	1.001 (0.995-1.007)	0.758
International normalized ratio	0.559	1.749 (0.936-3.268)	0.080
Width of portal vein	-0.002	0.998 (0.996-1.000)	0.063
HBeAg positivity	0.726	1.242 (0.681–2.267)	0.487
HBV DNA (log 10IU/mL)	0.828	1.237 (0.677–2.244)	0.567
NA(s) ETV/TDF	0.925	1.245 (0.755–1.956)	0.789

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBIL: Total bilirubin; ALB: Albumin; WBC: White blood cells; HBeAg: Hepatitis B e-antigen; NLR: Neutrophil–lymphocyte ratio; PLT: Platelet count; Cr: Creatinine; INR: International normalized ratio; NA(s): Nucleos(t)ide analogues; ETV: Entecavir; TDF: Tenofovir.